By Michael B. A. Oldstone,Hugh Rosen
ISBN-10: 3319058789
ISBN-13: 9783319058788
ISBN-10: 3319376039
ISBN-13: 9783319376035
This quantity specializes in the function of sphingosine-1-phosphate (S1P) and its analogs within the caused sequestration of lymphocytes in secondary lymphoid organs or within the microenvironment of tissues thinking about an infection or autoimmune illness. preliminary chapters outline the pathways to appreciate S1P signaling. They disguise the association of signaling platforms, the structural biology of the S1P1 receptor, and the chemical and genetic instruments which are on hand and important to discover this sector of study and therapeutics. The later chapters spotlight S1P and endothelial integrity, lymphocyte migration within the spleen, and S1P agonist in controlling immunopathologic manifestations of acute breathing influenza virus an infection (in the lung), and its accompanying cytokine hurricane in addition to immunopathologic illness of the vital apprehensive approach, together with the start of remedies in a number of sclerosis. One bankruptcy unearths the prospective involvement of different lipid molecules, their use for larger realizing lipid signaling, and their power within the modulation of immune responses.
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Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases (Current Topics in Microbiology and Immunology) by Michael B. A. Oldstone,Hugh Rosen
by Robert
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