By Charles F. George,David G. Shand
ISBN-10: 0407023224
ISBN-13: 9780407023222
Section 1 specializes in presystemic removal through the gastrointestinal tract. This part discusses the enzymatic biotransformation within the gastrointestinal mucosa and the power of the microflora to metabolize medications. part 2 considers the contribution of the liver to presystemic drug removing, with a selected emphasis at the physiological elements, which be certain the speed of breakdown of substances in vivo. This part additionally offers with the results of hepatic cirrhosis on presystemic drug removing. part three provides first a quick define of the information of pulmonary constitution and suitable body structure, through a dialogue on “first-pass metabolism of endogenous substrates and medicine around the pulmonary flow and of environmental chemical compounds after inhalation. This part additionally presents the equipment for distinguishing among the contribution of a few of the websites to presystemic drug removal and the issues linked to makes an attempt to research to be had pharmacokinetic facts.
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Presystemic Drug Elimination: Butterworths International Medical Reviews: Clinical Pharmacology and Therapeutics: Presystemic Drug Elimination v. 1 by Charles F. George,David G. Shand
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