By Jörg Holenz
ISBN-10: 3527333290
ISBN-13: 9783527333295
starting with a basic dialogue of the underlying ideas and methods, person lead iteration techniques are defined intimately, highlighting their strengths and weaknesses, besides all suitable bordering disciplines like e.g. aim id and validation, predictive tools, molecular reputation or lead caliber matrices. Novel lead new release ways for not easy pursuits like DNA-encoded library screening or chemical biology ways are taken care of the following part through aspect with proven equipment as excessive throughput and affinity screening, wisdom- or fragment-based lead new release, and collaborative ways. in the complete ebook, a truly robust concentration is given to focus on the appliance of the provided tools, in order that the reader might be capable of research from genuine existence examples. the ultimate a part of the ebook provides numerous lead iteration case reviews taken from diversified healing fields, together with diabetes, cardiovascular and respiration ailments, neuroscience, an infection and tropical diseases.
the result's a first-rate wisdom source for medicinal chemists and for each scientist considering lead generation.
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Lead Generation: Methods and Strategies (Methods and Principles in Medicinal Chemistry) by Jörg Holenz
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