By Rongshi Li,Jeffrey A. Stafford
ISBN-10: 0470278293
ISBN-13: 9780470278291
Since the invention of protein kinase job in 1954, the sphere of protein kinase drug discovery has complex dramatically. With the continued medical good fortune of the Bcr-Abl kinase inhibitor Gleevec within the remedy of continual myelogenous leukemia and 7 extra advertised kinase inhibitor medicinal drugs, researchers have compelling proof that kinase inhibitors will be hugely efficacious within the therapy of ailments brought on by aberrant job of protein kinase. at the moment greater than a hundred protein kinase inhibitors are in scientific development.
In one entire quantity, the editors, Dr. Rongshi Li and Dr. Jeffrey Stafford, current well timed and significant case stories of advertised kinase medicinal drugs and several other of the main complicated kinase inhibitors in medical trials. Kinase Inhibitor Drugs includes:
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Case reports from prime investigators and specialists within the box that supply firsthand debts of kinase inhibitor discovery
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Current pondering on kinase constitution, biochemistry, and sign transduction pathways
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Information on cutting-edge applied sciences and instruments reminiscent of structure-based and fragment-based drug discovery
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A lineup of clinical-phase development issue receptor inhibitors
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Inhibitors of mobile cycle kinases
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The discovery of allosteric inhibitors of MEK kinase
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Information on pharmacogenomics and its software to kinase inhibitor scientific development
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Kinase Inhibitor Drugs (Wiley Series in Drug Discovery and Development) by Rongshi Li,Jeffrey A. Stafford
by Christopher
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