By Susan M. Gasser,En Li
ISBN-10: 3034803052
ISBN-13: 9783034803052
ISBN-10: 3764389885
ISBN-13: 9783764389888
Recent biomedical curiosity during this regulatory process stems from the truth that epigenetic, not like genetic, adjustments are in precept amenable to pharmacological intervention. a number of epigenetically energetic medicinal drugs, for instance histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, were licensed by way of FDA for therapy of cancers akin to CTCL, MDS, and AML.
This quantity explores the medical heritage for medical purposes of epigenetically energetic medications. incorporated are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by way of RNA interference (RNAi) and microRNAs, in addition to new findings from stem phone learn that are proper to pharmacological applications.
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Epigenetics and Disease: Pharmaceutical Opportunities: 67 (Progress in Drug Research) by Susan M. Gasser,En Li
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