Pharmacology

Download PDF by Roger G. Pertwee (Ed.),Roger G. Pertwee: Cannabinoids: 168 (Handbook of Experimental Pharmacology)

By Roger G. Pertwee (Ed.),Roger G. Pertwee

ISBN-10: 354022565X

ISBN-13: 9783540225652

under twenty years in the past the ?eld of hashish and the cannabinoids was once nonetheless c- sidered a minor, a bit of old fashioned, region of study. a couple of teams have been lively within the ?eld, however it used to be already being considered as stagnating. The chemistry of hashish nine nine was once popular, ? -tetrahydrocannabinol (? -THC), identi?ed in 1964, being the one significant psychoactive constituent and cannabidiol, which isn't psychoactive, most likely contributing to a few of the results. those cannabinoids and several other s- thetic analogs have been completely investigated for his or her pharmacological results. Their mode of motion was once thought of to be non-speci?c. the explanations for this - sumption have been either technical and conceptual. at the technical aspect, it have been proven that THC was once lively in either enantiomeric types (though with a distinct point of efficiency) and this commentary was once incompatible with motion on organic substrates—a receptor, an enzyme, an ion channel—which react with a unmarried stereoisomer purely. The conceptual challenge regarding THC task. This were mentioned by way of a number of very popular study teams that had proven that the various results obvious with cannabinoids have been regarding these of biologically energetic lipophiles, and that some of the results of THC, rather persistent ones, have been similar to these obvious with anaesthetics and solvents.

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Cannabinoids: 168 (Handbook of Experimental Pharmacology) by Roger G. Pertwee (Ed.),Roger G. Pertwee


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